CAS號(hào) 6-0201 注冊(cè)證號(hào) 無 英文名 Rat hepatic stellate cells 庫(kù)存 50萬(wàn) 供應(yīng)商 齊氏生物 腫瘤類型 無 細(xì)胞類型 原代細(xì)胞 ATCC Number 詳詢 品系 SD RAT 組織來源 肝 相關(guān)疾病 正常 物種來源 大鼠 免疫類型 不詳 細(xì)胞形態(tài) 星型 器官來源 肝臟 年限 成年 生長(zhǎng)狀態(tài) 貼壁 是否是腫瘤細(xì)胞 否 運(yùn)輸方式 凍存快遞 規(guī)格 5×105 肝星狀細(xì)胞(Hepatic Stellate Cells) 是各種致纖維化因素的最終靶細(xì)胞,正常情況下肝星狀細(xì)胞處于靜止?fàn)顟B(tài),當(dāng)肝臟受到炎癥或機(jī)械刺激等損傷時(shí),肝星狀細(xì)胞被激活,其表型由靜止型轉(zhuǎn)變?yōu)榧せ钚汀? 應(yīng)用方向 1)HSC與肝纖維化 2)HSC與肝臟發(fā)育和再生 3)HSC與肝腫瘤 4)HSC與免疫系統(tǒng) 用戶反饋 (上圖為藥企研發(fā)部門提供) 2016-2019 論文引用(部分) Deng M, Xu L, Xie X et al., .Downregulation of syndecan?1 expression induces activation of hepatic stellate cells via the TGF?β1Smad3 signaling pathway. Mol Med Rep. 2019; 20(1):368-74. Zhang F, Lu S, He J et al., Ligand activation of PPARγ by ligustrazine suppresses pericyte functions of hepatic stellate cells via SMRT-mediated transrepression of HIF-1α. Theranostics 2018; 8(3): 610-26. Zhang F, Jin H, Wu L et al., Diallyl trisulfide suppresses oxidative stress-induced activation of hepatic stellate cells through production of hydrogen sulfide. Oxid Med Cell Longev. 2017; 2017:1406726. Lian N, Jin H, Zhang F et al., Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate‐activated protein kinase. IUBMB Life. 2016; 68(7):589-96. He L, Hou X, Fan F et al., Quercetin stimulates mitochondrial apoptosis dependent on activation of endoplasmic reticulum stress in hepatic stellate cells. Pharm Biol. 2016,; 54(12):3237-43. Zhang F, Lu C, Xu W et al., Curcumin raises lipid content by Wnt pathway in hepatic stellate cell. J Surg Res. 2016; 200(2): 460-6. 更多詳情,請(qǐng)咨詢